Nikki Waterhouse made her professional acting debut in the Australian TV mini-series Housemate. She was cast in the role of Dolly in 2 episodes of the comedy about a clean freak, Jude, who is dumped by his girlfriend and forced to find a housemate to pay the bills.
This role kickstarted an upward career trajectory with Nikki going on to appear in various roles on the small screen and in film.
Her credits include short films, The Broken, On Hold for Taylor, and Lesbian Western. She is known for her starring role in Zoe’s Security Service, a sci-fi thriller about a private military group hired to secure the borders of a futuristic city and its citizens.
Playing a massage therapist, Nikki appeared in 7 episodes of Australian comedy series Skit Marks. She also co-produced Skit Marks which aired in 2013 and spanned 17 episodes.
Nikki also starred as Kristy McMillian in The System, an Australian drama which follows Martin McMillan, a family man who suddenly finds himself redundant after 15 years of loyalty to the same company. Martin struggles to cope with the hardships of unemployment and today's society and loses his home, car and entire savings.
Other notable appearances include The Tail Job, Damaged and drama feature Sydney Stories. Released in 2021, Sydney Stories is an anthology of several short films, showcasing an international cast and crew telling all kinds of stories and shot over the course of 3 years in New South Wales, Australia.